Why the Warriors aren’t worried about Steph Curry’s struggles

first_imgCLICK HERE if you are having a problem viewing the photos on a mobile device[vemba-video id=”van/sc/2019/04/22/bang_be55fc57-df99-4c60-b8e7-676539109d9d”]Dieter Kurtenbach discusses the big games from Golden State Warriors’ Klay Thompson and Kevin DurantLOS ANGELES — Stephen Curry has been writing on his shoes since college.Every game since he was at Davidson, you could find Curry’s initials — WSC — and a reference to the Bible verse Philippians 4:13 — “I can do all things through Christ who …last_img read more

Are Embryonic Stem Cells Obsolete?

first_img Are embryonic and adult stem cells equal?:  “Ever since human induced pluripotent stem cells were first derived in 2007, scientists have wondered whether they were functionally equivalent to embryonic stem cells, which are sourced in early-stage embryos.”  The answer is: yes, they are.  Science Daily reported that a study published today at the University of Wisconsin-Madison showed that the protein products produced by the two sources of stem cells are 99% identical.  Repeated runs show the statistics are extremely robust; in fact, some of the products from embryonic stem cells more closely resembled those from induced pluripotent stem cells than they did from other embryonics, so any differences in that last 1% may be statistical noise. Endless supply:  Understanding the self-renewal process of adult stem cells was explained on PhysOrg.  “The promise of stem cells is two-fold: On one hand, they can differentiate into all the specialised cells in the tissues of the body and thereby guarantee tissue repair; on the other hand, they can self-renew and form new stem cells ensuring -at least in theory- an inexhaustible supply of cells in demand.”  The new finding is that “Scientists from the Friedrich Miescher Institute for Biomedical Research (FMI) are the first to establish a direct link between a conserved stem cell factor and the cell cycle regulation in adult stem cells.” Exercise:  Stem cell science is not just academic or about invalids.  You can steer your internal stem cells, PhysOrg said.  Research at McMaster University showed, “Exercise boosts health by influencing stem cells to become bone, not fat, researchers find.” Fountain of youth:  “Adult stem cells can be rejuvenated, simply by growing them in a youthful environment – at least in mice,” Linda Geddes reported on New Scientist.  “The discovery boosts hopes that adult human stem cells could be used to grow replacement tissue without the need for embryonic stem cells or complicated cell reprogramming.” Colon therapy:  Stem cells from the colon have been grown in a lab plate for the first time, reported Medical Xpress.  “This achievement opens up an exciting new area of research with the potential to bring about a huge breakthrough in regenerative medicine,” one of the researchers said, his thoughts turning to treatments for colon cancer and Crohn’s disease. Blood therapy assisted by sound:  Transplantation of hematopoietic stem cells is already an effective treatment for malignant blood diseases, Medical Xpress reported, but now researchers in Sweden have found the process can be enhanced using ultrasound. Neck vertebra restored:  In another exciting breakthrough, scientists at UC Davis found that stem cells can be used to re-grow damaged cervical disks between vertebrae in the neck.  Story on Medical Xpress. Preventing premature births:  An artificial amniotic membrane with human amniotic stem cells shows promise for helping women keep preemies at risk, said Medical Xpress.  “For pregnant women with a ruptured fetal membrane, the artificial AM can be used to replace the damaged area to allow her to carry the baby to term.” Tooth regeneration:  Two pockets of stem cells were identified in certain teeth of mice that grow continuously.  In PLoS ONE, researchers described how “the progeny move out of the stem cell niche and migrate toward the distal tip of the tooth.” Understanding the role of stem cells in teeth might help humans regrow damaged teeth, but first, the science.  “These studies point to miRNAs [micro-RNAs] that likely play a role in the renewal and differentiation of adult stem cells during stem cell-fueled incisor growth,” the team of California scientists reported.         Cell fate:  Understanding what causes stem cells to “decide” what tissue to become was discussed on PhysOrg.  Communication between cells is critical.  “When it comes to speaking out, cells wait their turn,” the headline reads.  A researcher at CalTech found a “mechanism that allows cells to switch from sender to receiver mode or vice versa, inhibiting their own signals while allowing them to receive information from other cells — controlling their development like a well-run business meeting.” Regulating the adult stem cell pool:  Another article on PhysOrg discussed the tight regulation of adult stem cells so that they do not develop into cancer.  “A study from Children’s Hospital Boston finds that a network of genes crucial in embryonic development may also keep tight [sic] rein on adult stem cells in the lung and other tissues, particularly as these cells rally to repair tissue damage.” Simplified freshness:  Science Daily told how researchers at RIKEN have reduced down to one the number of factors required to keep induced pluripotent stem cell populations fresh.  “Key Protein Reveals Secret of Stem Cell Pluripotency,” the headline read. Adult stem cells can apparently do everything embryonic stem cells can – and they are moving regenerative medicine forward faster, with more results.  Since the use of human embryos for research is ethically repugnant to many people, what motivations remain to continue the practice?  Here is a rapid-fire list of stem cell news this month: So what are embryonic stem cells good for?  Medical Xpress talked about research to repair damaged retinas from bandages infused with retinal cells derived from embryonic stem cells, but it was not clear that adult stem cells or induced pluripotent stem cells (iPSC) couldn’t work just as well.  In another article on PhysOrg, researchers were said to have overcome a major obstacle for purifying stem cells; they worked on both embryonic and iPSCs, but again, it was not clear that embryonic stem cells offered any advantage.  The BBC News reported on the first clinical trials of fetal stem cells injected to repair brain damage from stroke, but the only news so far is that the doctors have not noticed any ill effects (yet) – not that brain tissue is getting healed.  A veiled apology was apparent in the article: “Critics object as brain cells from a foetus were originally used to create the cell treatment,” reporter Pallab Ghosh wrote.  “Michael Hunt, Chief Executive Officer of the company that produced the stem cells, Renuron, said that the technology used to grow the cells is such that no further foetal tissue will be required.” As the first article quoted above stated, “the newer form, called IPS cells, have two advantages. They face less ethical constraint, as they do not require embryos. And they could be more useful in cell replacement therapies: growing them from the patient’s own cells would avoid immune rejection.”  Now that adult stem cells and IPS cells have taken the lead on actual treatments in the booming field of regenerative medicine, it seems the burden is now on embryonic stem cell researchers to explain why they need to tinker with human embryos at all. The wonderful news from adult stem cells discussed above needs to be seen against a disturbing historical backdrop.  Not so many years ago, not long after 9/11, the scientific institutions were screaming for federal funding for embryonic stem cells, ridiculing anybody who stood in their way (like President George Bush) as ignorant obstructionists who would leave America in the dust of other nations in the quest for a Nobel Prize, all because of a few questionable worries about ethics.  Tear-jerking commercials tugged on the heartstrings of Americans, pleading for access to human embryos so that Christopher Reeve might walk again (he didn’t), or Michael J. Fox might be cured of Parkinson’s Disease.  My, how times have changed.  The Hwang scandal, followed by the discovery of iPSCs, and the rapid growth of adult stem cell therapy, has made stem cell research a new ball game. But the game isn’t over.  Researchers are still using taxpayer dollars to experiment on human embryos, and the current administration and the courts are still giving them all they want.  Citizens need to realize they have a responsibility to keep scientists under control.  Scientists need a certain amount of autonomy, since one never knows where a fundamental breakthrough will emerge, but no scientist should get carte blanche to do anything.  The history of the 20th century showed that horrible atrocities can be committed under the guise of scientific research.  Ethics is to publicly-funded science what a bridle is to a horse.  A good workhorse needs its head, if it is well-trained and already knows where the owner wants it to go, but sometimes the rider (an informed public) needs to yank the reins when the horse gets ornery.  This would be a good time to yank the public funding from the snorting, out-of-control stem cell science snobs.  Bad Charlie!(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

MRTN – Maximum return to N

first_imgShare Facebook Twitter Google + LinkedIn Pinterest So how do we make nitrogen (N) recommendations in Ohio? Current recommendations from Ohio State University use an economic model to set our corn nitrogen rate. The Maximum Return To N (MRTN) concept was developed by soil fertility specialists from across the north central region: this is a regional Corn Belt wide approach for nitrogen rates.For us, we use data from trials in Ohio so we also have our weather included as part of the equation and we factor in the price of nitrogen and the value of corn to bring in the economics. Chart 1 shows that our best economic return to nitrogen for $3.50 corn and $0.40 per pound of N is about 168 pounds of N per acre with a range of about 15 pounds to either side giving us about the same economic return –— within $1. You may also gain efficiency by delaying the bulk of your N application until sidedress timing. From last year’s experience, you’d better put 30 to 50 N units with your corn at planting, though, and then you can sidedress the remainder later.The calculator for this MRTN is available on the Iowa State University website: http://extension.agron.iastate.edu/soilfertility/nrate.aspx. You can go there to get the best suggestion on your nitrogen rate, even run some different scenarios. You’ll need to know:Your statePrevious crop – corn or soybeansPrice of NExpected sales price for a bushel of corn.The MRTN housed at Iowa State does use Ohio data from a range of years that we provided after conducting trials on Ohio research sites and farms across several years. Have you read the Tri-State Recommendations for corn, soybeans, wheat and alfalfa?Most folks say they have not. But if you had, you could say you understand the principles behind the recommendations and trust them to be quite valuable. While no longer printed, it is available as a pdf on-line: http://agcrops.osu.edu/publications/tri-state-fertility-guide-corn-soybean-wheat-and-alfalfa.A few of the principles in the Tri-State for P and K management:You should soil test every three to four years, results are presented in ppm, and correct application rates as necessary.Expected grain nutrient removal as: For P2O5 – corn 0.37, soybean 0.80, and wheat 0.63-pound removal per bushel. For K2O removal  — corn 0.27, soybean 1.40, wheat 0.37-pound removal per bushel.Recommendations are designed to provide adequate nutrition for the crop, and to create or maintain a soil capable of providing sufficient nutrient without fertilizer addition for one or more years.We follow a philosophy of build up for low testing soils, maintain levels above the critical level in the maintenance plateau, or drawdown at high nutrient levels to maximize crop yieldAnd key to these recommendations is field calibration and correlation studies that have been conducted over the past 40 yearsRecently our Ohio State University soil fertility specialist along with his research team — Dr. Steve Culman with Muhammad Tariq Saeed and Anthony Fulford — dug through the data from Ohio that was used to develop the tri-state recommendations. The Tri-State Fertilizer Recommendations, published in 1995, provided a unified soil fertility framework between Michigan, Ohio and Indiana.At Ohio State, Dr. Jay Johnson was the Soil Fertility Specialist who conducted field trials and developed the fertilizer recommendations. From 1976 to 1999, Dr. Johnson reported the results of his field trials from each field season in an annual report. The group went through these reports and pulled out every field trial that looked at phosphorus or potassium fertilization. They found 85 Phosphorus (P) trials conducted over eight sites: 47 in corn, 33 in soybeans and five in wheat. And they also found 102 Potassium (K) trials conducted over eight sites: 68 in corn, 32 in soybeans and two in wheat.For each trial, they calculated the percentage of relative grain yield by dividing the yield of the unfertilized plots by the yield of the fertilized plots and multiplying the result by 100. Since yields can vary greatly over sites and years, they use relative yield to show us how much fertilization increased or decreased grain yields. For each trial, they then took the relative yield and graphed it against the soil test P or K level.Figure 1 shows this relationship with P and Figure 2 shows the relationship with K. Each dot represents a single field trial from one year. The solid black horizontal line at 100% represents no change between unfertilized and fertilized plots. The dotted black line at 90% shows a 10% reduction in yield. The dashed vertical line shows the Tri-State critical levels of 15 ppm Bray P1 (Figure 1) and 100 ppm Ammonium Acetate K (Figure 2).These are the data from Ohio that helped establish the critical soil test P and K levels found in the Tri-State Fertilizer Recommendations.A field with soil test levels to the left of the vertical dashed line has a reasonable chance of a yield response to fertilization and so fertilizer is recommended, while fields with soil test levels higher than the dashed line have a very low chance of a yield response to fertilizer, and so little to no fertilizer is recommended.While we have confidence in past trial work, Steve suggests we can consider this information “historic” or “old” and that efforts underway will help produce ‘current’ information to see if the fertilizer recommendations need to be revised. You can imagine how much collective effort will be required to generate robust information across the state. Steve, and all of the agronomic crops team, is looking for farmer cooperators to conduct on-farm strip trials to help generate additional information. More information on how to participate in these field trials can be found here: http://go.osu.edu/fert-trialslast_img read more

Check out Geocaching.com’s new look!

first_imgWe’re always striving to make better tools for the geocaching community. The addition of the new geocache search and Hide a Geocache page gave us an opportunity to think about how players navigate Geocaching.com. We found that most players who visit the website want to either learn about geocaching, play the game, gear up, or connect with the global geocaching community. The new navigation should help guide you to find exactly what you’re looking for —  and leave the hunting around for when you’re in the field!What’s new:How do I access My Profile? Click on your geocaching username or your profile image. This will take you to My Profile where you can access Lists, Geocaches, Trackable Items, Souvenirs, and more. How do I access Account Settings?Look for the gear icon in the drop down under your username.Where can I see my membership status?You can see your membership status listed in Account Settings or My Profile.Why is the font different on the website?You have good eyes! In the name of consistency, we updated the font to be the same across Geocaching.com.Oh no! My geocaching scripts aren’t working anymore. When will you fix these?These scripts are made and maintained by members of the geocaching community, not by Geocaching HQ. Occasionally, updates like this will stop them from working. Usually, the geocachers who own and maintain the scripts are quick to fix them. Thanks for being patient!How do I find…?Sometimes less is more. These pages did not make it into the new navigation but you can still find them on our website here:Guide to Buying a GPS DeviceGeocaching & EducationGeocaching BrochuresGeocaching Tools and DownloadsAdvertising with UsAPI ProgramSignal the FrogGeocaching in the NewsBenchmark HuntingGeocaching HistoryLocal Organizations (Note: Getting involved with a geocaching organization is one of the best ways to take your game to the next level. You can also learn more about organizations here.) Share with your Friends:More SharePrint Relatedlast_img read more

6 Sites to Make You a Better Filmmaker

first_imgImprove your scriptwriting, filmmaking and film theory knowledge with these helpful sites.Image from Vancouver Film School on FlickrIt often seems that new filmmakers are obsessed with gear and technology, but don’t focus on how to tell a story. If you’re looking to dig deeper into film theory and learn how the best moving stories are told, these filmmaking sites provide a wealth of info. Bookmark them!Film CourageFim Courage  is co-run by Karen Worden (Editor-in-Chief/videographer) and David Branin (videographer). The site provides a ton filmmaking tips and tricks from professional filmmakers in the industry.  Also worth checking out is their Director’s Toolkit that has interviews with successful filmmakers like Richard Linklater.Fincher FanaticAs the name indicates, Fincher Fanatic is focused on the Films of David Fincher. But don’t let that put you off, as it offers the site is actually a lot more comprehensive and features articles/videos on the process of filmmaking. I suggest starting in the “Film School” section, featuring a variety of interesting articles and videos.One of my favorites is Paint It Black: A Look at David Fincher’s Color Palette ,a PDF that looks at the use of color in several Fincher films. It’s a very enlightening 9 page read, especially for those interested in learning cinematography and color grading.Movies in ColorMovies in Color touts itself as “a website featuring stills from films and their corresponding color palettes. A tool to promote learning and inspiration”. The site examines color palettes from well known Hollywood classics, as well as recent films.Color is an essential part of mise-en-scène. I find this site fascinating and have been revisiting some of favorite films while referencing the color swatches here. You can search the site based on the film, director or cinematographer. For those wanting to work in cinematography and color grading, understanding color is essential.Related to this, Mike Jones has a great article on color grading that covers building color swatches for your film/video project.Clothes on Film“The aim of Clothes on Film is to examine costume and identity in movies, featuring detailed articles on outfits, reviews, news and exclusive interviews”Although the blog seems like an ideal read for a costumer, there’s actually a lot of considerations here for anyone interested in filmmaking. Unfortunately clothes and costuming is often neglected in low budget filmmaking. The right clothing can help better convey a sense of time and feeling in your film project.David Bordell Geared toward the student filmmaker, Elements of Cinema is a good starting point for those interested in the fundmentals of successful filmmaking. The site provides a detailed guide to the process, from screenwriting and editing to directing and cinematography.For those new to the craft, start on the What is Cinema page.These sites provide a wealth of info on the different aspects of filmmaking. Got others to share? Let us know in the comments below. David Bordell is the author of the well known book  Film Art and a Professor of Film Studies at the University of Wisconsin–Madison. His articles are detailed observations on both historical and contemporary cinema. The site feels slightly academic, but there is great info here and definitely worth a read.One of his most recent post is a fascinating look at the storytelling process of the ‘Wolf of Wall Street“. It’s a terrific read on the fundamentals of film narrative.Elements of Cinemalast_img read more